Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression.

The Mitotic Arrest in Response to Hypoxia and of Polar Bodies during Early Embryogenesis Requires Drosophila Mps1

Mps1 kinase plays an evolutionary conserved role in the mitotic spindle checkpoint. This system precludes anaphase onset until all chromosomes have successfully attached to spindle microtubules via their kinetochores. Mps1 overexpression in budding yeast is sufficient to trigger a mitotic arrest, which is dependent on the other mitotic checkpoint components, Bub1, Bub3, Mad1, Mad2, and Mad3. Th...

Mps1 activation loop autophosphorylation enhances kinase activity.

The Mps1 protein kinase is required for proper assembly of the mitotic spindle, checkpoint signaling, and several other aspects of cell growth and differentiation. Mps1 regulation is mediated by cell cycle-dependent changes in transcription and protein level. There is also a strong correlation between hyperphosphorylated mitotic forms of Mps1 and increased kinase activity. We investigated the r...

Human Mps1 Kinase is required for the Mitotic Spindle Checkpoint, but not for Centrosome Duplication

Mitotic Protein Kinase 1: Role in Spindle Assembly Checkpoint Revisited

Cell division is a highly regulated process and involves sequential activation and deactivation of a number of proteins. Mitotic protein kinase (MPS1) is a part of the spindle assembly checkpoint (SAC) activated during prometaphase and metaphase that prevents chromosome misalignment by arresting the cell in mid-mitosis until all of the chromosomes is properly attached to the mitotic spindle [1]...

Mps1 as a link between centrosomes and genomic instability.

Centrosomes are microtubule-organizing centers that must be precisely duplicated before mitosis. Centrosomes regulate mitotic spindle assembly, and the presence of excess centrosomes leads to the production of aberrant mitotic spindles which generate chromosome segregation errors. Many human tumors possess excess centrosomes that lead to the production of abnormal spindles in situ. In some tumo...